Studies on the Coagulation of Chicken Blood. VI. Use of Cobalt Carbonate, Barium Phosphate, Lead Carbonate and Lead Phosphate for Differentiation and Assay of Strontium Carbonate Non-adsorbable Labile Factors.

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Abstract
Results obtained with fifty-two selected crystalline adsorbents are explained as adsorption of four different labile coagulation factors by four different groups of adsorbents, represented by the title compounds. Provisional names for these factors are suggested [LAMBDA] (lambda)-factor is selectively adsorbed by cobalt carbonate, rr(pi)-factor by lead carbonate, [beta] (beta)-factor by lead phosphate, and [gamma](gamma)-factor by barium phosphate. The activity of [LAMBDA]-factor is independent of the concentrations of the other three factors. The activities of [beta]- and 77-factors are also mutually independent, whereas [gamma]-factor acts as a syngerist both for it-factor and for [beta]-factor. When Russell''s viper venom (RVV), with or without cephalin, is substituted for thromboplastin in the assay system,y- and rr-factors are inactive. [beta]- Factor is active only if RVV is supplemented with cephalin. -[LAMBDA] Factor is part of the labile factor activity measured by all three assay accelerators. Determination of the minimum amount of the adsorbents required for maximal adsorption of labile factor activity is suggested as a possibility for quantitative determination of the adsorbable factors.