Alternative Types of Duodenal Ulcer Induced in Mice by Partial X Irradiation of the Thorax

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Abstract
Earlier observations [Michalowski, (1981); Michalowski and Burgin (1982)] on gastrointestinal pathology in thorax-irradiated female CFLP mice were extended. Apparently, exposure of the lower mediastinum to single doses of 14-30 Gy [Gray] X-rays results in the formation of the proximal duodenal ulcer accompanied frequently by erosion of the antral gastric mucosa. X irradiation of the later thoracic fields is responsible for single ulcers in the proximity of duodenal papilla, often associated with a circumscribed area of degeneration of the fundic mucosa of the stomach. In view of the small amount of radiation received by the subdiaphragmatic parts of the alimentary tract, these gastro-duodenal lesions represent abscopal effects of thoracic irradiation.