Decrease in Serum Alkaline Phosphatase Activity Produced by Magnesium Depletion in Rats.
- 1 October 1966
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 123 (1) , 201-203
- https://doi.org/10.3181/00379727-123-31441
Abstract
Summary Thirty-day-old rats were fed a magnesium-deficient diet for up to 34 days. There was a decrease in serum alkaline phos-phatase activity which was reversed by adding magnesium chloride to the diet. The rats also developed hypophosphatemia and were mildly hypercalcemic for 14 days. Approximately one-third of the rats had phosphoethanolamin-uria. These changes are similar to those seen in infantile hypophosphatasia in man. Magnesium deficiency in rats may induce a biochemical lesion similar to that of hypophosphatasia in man.This publication has 6 references indexed in Scilit:
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