Studies on Severe Alcohol Intoxication in Dogs. III. Effect of Adrenalectomy

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Abstract
The oral administration to 7 intact dogs of 8 ml of absolute alcohol per kg of body weight produced the following effects: (a) an increase in plasma glucose; (b) a transient decrease in plasma K; (c) an increase in hematocrit values; (d) a sustained decrease in erythrocyte sedimentation rate; (e) an initial increase in plasma Na, followed by a decrease; (f) an oliguria during the early phase of intoxication with a subsequent diuresis during recovery; and (g) no alteration in blood urea N. The administration of the same dose of alcohol to 10 bilaterally adrenalectomized dogs resulted in the following effects: (a) an increase in plasma glucose of significantly smaller magnitude than in intact dogs; (b) no significant alteration in plasma K; (c) an increase in hematocrit values; (d) a sustained decrease in erythrocyte sedimentation rate; (e) no significant alteration in plasma Na; (f) an increase in blood urea N during the later phase of intoxication and during recovery; and (g) an initial diuresis followed by a sustained oliguria. The oral administration to 9 intact dogs of 4 ml of absolute alcohol per kg produced the following effects: (a) an increase in plasma glucose of a lower order than with the 8 ml per kg dose; (b) a sustained decrease in plasma K; and (c) no significant alteration in hematocrit values, erythrocyte sedimentation rate or plasma Na levels.

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