Studies on macrocyclic lactone antibiotics. VI. Skeletal structure of copiamycin.
- 1 January 1982
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 35 (11) , 1480-1494
- https://doi.org/10.7164/antibiotics.35.1480
Abstract
The skeletal structure of copiamycin (C54H95N3O17), a potent antifungal antibiotic, was determined from the physicochemical properties of this compound and of its degradation products. This compound consists of a 32-membered polyhydroxy lactone ring, an .alpha.,.beta.-unsaturated ester group and a side chain with a disubstituted guanidine moiety as its terminal. One of the hydroxyl groups (presumably at C-19) forms a hemiketal ring with the keto group at C-15, and another (at C-21 or C-23) forms a hemiester with a malonic acid moiety.This publication has 4 references indexed in Scilit:
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