Histopathological study on rats fed iodine-enriched eggs long-term (7 and 19 months).

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Abstract
A histopathological study was conducted on rats fed on a long term diet containing I-enriched eggs, 7 and 19 mo. A laboratory powder chow was added at the 1% (wt/wt) level with ordinary egg powder (ordinary egg diet as control: 35 .mu.g I/100 g diet) or I-enriched egg powder (I-enriched egg diet: 392 .mu.g I/100 g diet). The animals were meal-fed twice a day and allowed unrestricted voluntary wheel-running. In general, organs, tissues and endocrine glands including thyroid glands from rats of the I-enriched egg diet group exhibited no significant differences in histopathological features as compared with those of the ordinary egg diet group. Apparently, long-term feeding of a considerable amount of I through an I-enriched egg diet did not cause any specific excess-I toxicity.