The effect of topical cyclosporin A on the rabbit cornea
- 1 November 1986
- journal article
- conference paper
- Published by Springer Nature in Albrecht von Graefes Archiv für Ophthalmologie
- Vol. 224 (6) , 520-524
- https://doi.org/10.1007/bf02154739
Abstract
To investigate the effect of topical cyclosporin A (CSA) on the rabbit cornea, both eyes of 80 animals were treated with CSA 2% eye drops over a 3-week period under various conditions. CSA was dissolved in castor oil or ethanol 13.8 vol. %. Slit-lamp, scanning and transmission electron microscopic examinations were performed. CSA 2% in castor oil given 5 times daily showed no damage to either the corneal epithelium or endothelium. In contrast the solutions containing ethanol revealed considerable epithelial cell damage.This publication has 13 references indexed in Scilit:
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