AMNIOTIC-FLUID VOLUME AND COMPOSITION FOLLOWING EXPERIMENTAL MANIPULATIONS IN SHEEP

  • 1 January 1980
    • journal article
    • research article
    • Vol. 56  (4) , 451-458
Abstract
Some 20-30% of amniotic fluid volume was replaced by isotonic solutions of saline, mannitol or dextrose in chronically cannulated ovine fetuses. The Na, K and Cl concentrations returned to control values in 3 to 6 h. Urea and creatinine behaved similarly in the saline and mannitol experiments but rose above control values within 1 h of dextrose replacement. Amniotic fluid volume increased with return of solute. Fetal urine drainage to the exterior abolished the rapid return of urea and creatinine concentrations in the dextrose experiments, although no changes in renal function occurred in any experiments. Evidently dextrose inhibited the exit of urea and creatinine from the amniotic compartment.