Effect of Organic Acids on Streptomycin Activity.,

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Abstract
Pyruvic and fumaric acids neutralize the effect of streptomycin upon Escherichia coli. 1% of these acids enables the organism to grow in the presence of 10 [gamma]/ml. of streptomycin, whereas in the presence of 3% of these acids growth took place even with 150 [gamma]/ml. of streptomycin. The organism growing in the presence of streptomycin and of the organic acids would not become resistant to streptomycin. Certain other organic acids such as succinic, formic, malic, and maleic also had an antagonistic effect upon streptomycin. The effect of these acids varied greatly with the organisms. E. coli and Proteus vulgaris were protected by the organic acids against the action of streptomycin, whereas Aerobacter aerogenes and Staphylo-coccus aureus were only slightly affected.

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