Lability of renal papillary tissue composition in the rat.

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Abstract
Acute effects of a minor operative procedure using ether as the anesthetic and the administration of 0.9% saline as a single i.v. injection in the conscious rat, on renal tissue composition were studied in hydropenic and normally hydrated rats. The operative procedure and anesthesia induced a rapid and transient decrease in papillary osmolality in hydropenic and normally hydrated animals, and the important contributing factor was a significant decrease in urea content. Administration of a small volume of saline caused a rapid decrease in urea content and increase in water content. Papillary composition apparently was extremely labile, large changes produced by relatively minor experimental procedures.