EVALUATION OF VARIOUS NUTRITIONAL SUPPLEMENTS IN THE PREVENTION OF STRESS-INDUCED GASTRIC-ULCERS IN THE RAT

  • 1 January 1984
    • journal article
    • research article
    • Vol. 158  (2) , 124-128
Abstract
The effectiveness of various nutritional supplements in preventing stress-induced gastric ulcers was studied in rats. Male rats were restrained on a board, divided into 9 groups and orogastrically infused with 1 of 4 commercial nutritional supplements, 25% glucose solution, normal saline solution or antacids. The other groups received either cimetidine or no treatment. The rats were sacrificed at the end of 4 h, and all ulcers were counted. Any solution providing calories, including 25% glucose solution, afforded significant protection against ulceration. While the antacids were better than no treatment, they were significantly worse than any nutritional supplement. Liminal substrates markedly increase the ability of the gastric mucosa of the rat to resist ulceration.