Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas—The effect of capping the distal basic piperidine nitrogen
- 11 September 2008
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 18 (20) , 5443-5447
- https://doi.org/10.1016/j.bmcl.2008.09.032
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesBioorganic & Medicinal Chemistry Letters, 2008
- Novel Selective Allosteric Activator of the M1Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in RatsJournal of Neuroscience, 2008
- Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffoldBioorganic & Medicinal Chemistry Letters, 2008
- Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHABioorganic & Medicinal Chemistry Letters, 2007
- DystoniaNew England Journal of Medicine, 2006
- Probing the Molecular Mechanism of Interaction between 4-n-Butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the Muscarinic M1 Receptor: Direct Pharmacological Evidence That AC-42 Is an Allosteric AgonistMolecular Pharmacology, 2006
- A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5Molecular Pharmacology, 2003
- Muscarinic receptor ligands and their therapeutic potentialCurrent Opinion in Chemical Biology, 1999
- Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genesNeuron, 1988
- Identification of a Family of Muscarinic Acetylcholine Receptor GenesScience, 1987