OESTROGEN TREATMENT IN CASES OF RUDIMENTARY OVARY SYNDROME

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Abstract
Results of estrogenic treatment in 29 cases with a syndrome of rudimentary ovary, some followed up for over 6 years, were discussed. Estrogens produced rapid reactions in a definite order: uterine cervix, vaginal and urethral mucosae, vulva, mammary gland; later there were changes in skin, height, body hair and mental reactions and finally in the appearance of menstruation. Suspension of treatment caused immediate relapse so that implantation of pellets of estradiol was recommended since they retained their activity for as long as 2 years and could be replaced when exhausted. Treatment by mouth with uniform doses of estrogens produced a less marked response in the genital organs, especially in the endometrium, and the dose had to be increased after several months or years in order to maintain the level of response. Several patients suffered from digestive intolerance to estrogens which did not occur in those treated by pellet implantation.