Ascorbic Acid and Ethylene Diamine Tetraacetate as Antidotes in Experimental Vanadium Poisoning

Abstract
Ascorbic acid antagonizes the toxicity of V in mice when admn. prior to V. Antidotal effects of monocalcium disodium ethylene diamine tetraacetate and ascorbic acid were demonstrated in V-poisoned rats and dogs, and ascorbic acid was probably the more rapidly-acting of the 2 antidotes. On the basis of in vitro polarographic studies, reduction of the V is suggested as a possible mode of detoxication of V.

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