Lymphomatoid papulosis followed by large-cell lymphoma: immunophenotypical and genotypical analysis
- 1 May 1991
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 124 (5) , 465-469
- https://doi.org/10.1111/j.1365-2133.1991.tb00627.x
Abstract
The immunophenotype and genotype of atypical cells in skin and lymph node infiltrates were investigated in a patient with lymphomatoid papulosis (LyP) complicated by anaplastic large-cell lymphoma of the lymph nodes. The large atypical cells in both skin and lymph nodes displayed an almost identical immunophenotype, i.e. CD30+ and CD25+. Southern blot analysis for T-cell receptor beta-chain gene rearrangement revealed an identical gene configuration in DNA extracted from skin and lymph node. Our results strongly support the hypothesis that clonal populations of T cells arising in cutaneous LyP lesions may undergo malignant transformation, spread into regional lymph nodes, and give rise to secondary malignant lymphomas, such as anaplastic large-cell lymphoma.Keywords
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