Effects of Cortisone on Cellular Inflammation in the Musculature of Mice Given One Infection with Trichinella spiralis

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Abstract
Daily cortisone treat-ment of mice for 30 days after an initial infection with T. spiralis resulted in almost complete suppression of the normal cellular infiltration into the musculature in response to invading larval worms. A shorter period of treatment with cortisone, terminating on the 13th day after infection, did not prevent the development of a striking general myositis as measured at 21 and 30 days after infection. Despite this striking cellular response there was no reduction in the number of larvae recovered from the musculature. Therefore, if this response is related to an immune action against the larvae, it requires longer than 30 days to produce demonstrable effects.