Changes in Plasma Prothrombin, Ac-Globulin, and Antithrombin Concentration Following Intravenous Administration of Estrogens.

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Abstract
An estrogen (Premarin) was administered intravenously to dogs. There was a sharp rise in the plasma Ac-globulin and prothrombin concentration. These changes began within 15 minutes and reached a peak in about 1 and 0.5 hours. In 3 to 4 hours normal concentrations were again approached. A small decrease in antithrombin activity of the plasma was also found which paralleled the above alterations in time.