Effect of the Destruction of Hypothalamus on the Suprarenal Response of the Rat to Total Body Irradiation

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Abstract
In the adult rat irradiated 2 days after destruction of the hypothalamus, the early reversible reaction of the suprarenals (90 minutes to 3 hours) to a total-body dose of 850 r of 200 kV X-rays, is abolished and no drop in ascorbic acid and cholesterol content is observed. This confirms the part played by the central nervous system in the neuro-endocrine reaction following severe irradiation. The most sensitive tissue from which the reaction starts is the central nervous system. These observations do not help intepret the mechanism and meaning of the late suprarenal reaction which begins 2 days after irradiation and continues until death.