STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. V. THE ANTIMALARIAL ACTIVITY OF QUINACRINE 123

Open Access
Publisher Website
Google Scholar
Abstract
The suppressive antimalarial activity of quinacrine has been examined in both vivax and falciparum infections induced by blood inoculation. The data presented describe the relationship between plasma quinacrine concns., oral dosage, and the therapeutic results, and define the range of effective plasma quinacrine concns. in malarial infections due to selected strains of plasmodia. The susceptibility of the erythrocytic phase of malaria to quinacrine action varies with the sp. and strain of the parasite. However, the information derived from these studies permits an appraisal of the adequacy of currently recommended dosage schedules for the suppression and treatment of malaria.