Influence of Aldosterone and Angiotensin II on Endotoxin Shock in the Primate.

Publisher Website
Google Scholar
Abstract
Severe endotoxin shock in monkeys resulted in hypotension, oliguria or anuria, hyperkalemia and death. No characteristic electrocardiographic findings were elicited. Aldosterone and angiotensin II were employed alone and in combination in attempts to reverse the shock. The most favorable results were obtained with a combination of the steroid and pressor drug. As in canine endotoxin shock, aldosterone markedly potentiated the pressor action of angiotensin II. Optimum results were correlated with the amount of aldosterone administered.