THE LOSS OF ESTROGEN-PROTEIN BINDING CAPACITY IN RAT HEPATOMA1

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Abstract
Studies of an enzyme system in rat liver capable of promoting the binding of estrone-16-C14 or its isotopic metabolites to the proteins of the homologous serum incubation medium were extended. Primary and transplanted hepatomatous tissues were shown to be defective in this regard. Additional aberrations of estrone metabolism were shown in the presence of neoplastic tissues. Recovery of radio-isotope bound to liver proteins was also significantly and consistently depressed. Tumor tissue was less effective than normal liver in transforming the steroid to unidentified metabolites. The possible relationship of these findings to known alterations in liver composition during tumorigenesis was discussed.