Haemophilia Due to Combined Deficiency of AHG, PTC and PTA Factors

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Abstract
A male presenting clinical symptoms of classic hemophilia from childhood, revealed that the patient''s hemorrhagic diathesis was due to a combined deficiency of the AHG, PTC and PTA factors. Some of his family members exhibited a mild disturbance of blood coagulation, obviously due to the partial deficiency of one or more factors. Nine cases of hemophilia due to a deficiency of more than one factor, reported so far in the literature are reviewed and the possible explanation of the relatively fragment appearance of such a combination from the pathogenetical point of view is discussed.