Coagulation studies in cerebrovascular disease

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Abstract
Of 120 patients with acute nonhemorrhagic strokes surveyed for possible hyperocagulable abnormalities with a coagulation test battery, 100 or 83% revealed such hypercoagulable abnormalities. The most frequent test abnormality was decreased antithrombin. This suggests that a decrease of clot inhibitor in this study often resulted in a hypercoagulable state. A smaller number of patients were noted to have either a combination of coexisting hyper- and hypocoagulable abnormalities or hypocoagulable changes alone. The relationship between such hypercoagulable changes and the pathogenesis of stroke syndromes is discussed.