The Influence of Ethanol Upon Maintained Water Diuresis in Man

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Abstract
The influence of ethanol administration upon the decline in rate of urine flow, which characteristically occurs when a large water load is maintained in the seated normal subject was studied. Administration of alcohol, a potent inhibitor of antidiuretic hormone (ADH) release, usually failed to raise the rate of flow or to lower the concentration of the urine. It is inferred that virtually complete physiologic diabetes insipidus may be maintained by maintenance of a large water load and that the decline in rate of water diuresis does not require ADH release.