Broad-Spectrum Möbius Syndrome Associated with a 1;11 Chromosome Translocation
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Ophthalmic Paediatrics and Genetics
- Vol. 14 (1) , 17-21
- https://doi.org/10.3109/13816819309087618
Abstract
The authors report a case of Möbius syndrome with Poland syndrome, cleft palate, dextrocardia, mandibular hypoplasia, and multiple areas of diffuse brain volume loss. Karyotype demonstrated a t(1;11)(p22;p13) translocation in the patient and his phenotypically normal father and brother. This case extends the spectrum of congenital disorders that are associated with Mobius syndrome and raises the possibility of genetic heterogeneity for the Möbius disorder.Keywords
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