Palladium Catalysis in the Preparation of Alkynylpyrimidines.
- 1 January 1986
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 40b (5) , 381-386
- https://doi.org/10.3891/acta.chem.scand.40b-0381
Abstract
4-Ethynyl derivatives of 5-chloro-2-methylthiopyrimidines, and of 5-chloro-2(1H)-pyrimidinones as trimethylsilyl derivatives, have been prepared by cross-coupling reactions between 4-iodopyrimidines and acetylenes using palladium catalysis. Reactions for the conversion of the coupling products to 2(1H)-pyrimidinones are described. Simple 4-alkynyl derivatives of 2(1H)-pyrimidinones are sensitive to alkali, especially the free acetylenic derivative. Phenyl substitution of the acetylenic function gave chemically stable compounds.This publication has 4 references indexed in Scilit:
- Structure Investigations on Products from the Reaction of Organocopper, Organolithium and Organomagnesium Reagents with 2(1H)-Pyrimidinones.Acta Chemica Scandinavica, 1985
- Regioselectivity in the reactions of aryltri-isopropoxytitanium with pyrimidinones.Journal of the Chemical Society, Perkin Transactions 1, 1985
- The reformatsky reaction of 1‐aryl‐2(1H)pyrimidinonesJournal of Heterocyclic Chemistry, 1983
- Pyrimidones 1. Synthesis of some 1‐substituted‐5‐aryl‐ and (4,5‐diaryl)‐2(1H)pyrimidonesJournal of Heterocyclic Chemistry, 1979