Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
- 1 March 2009
- journal article
- review article
- Published by Elsevier in Trends in Pharmacological Sciences
- Vol. 30 (3) , 148-155
- https://doi.org/10.1016/j.tips.2008.12.002
Abstract
No abstract availableThis publication has 52 references indexed in Scilit:
- Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of ActivityMolecular Pharmacology, 2009
- Mutagenic Mapping Suggests a Novel Binding Mode for Selective Agonists of M1 Muscarinic Acetylcholine ReceptorsMolecular Pharmacology, 2009
- Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disordersNature Reviews Drug Discovery, 2009
- Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in RatsThe Journal of Pharmacology and Experimental Therapeutics, 2008
- Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesBioorganic & Medicinal Chemistry Letters, 2008
- Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas—The effect of capping the distal basic piperidine nitrogenBioorganic & Medicinal Chemistry Letters, 2008
- Allosteric modulation of the muscarinic M4receptor as an approach to treating schizophreniaProceedings of the National Academy of Sciences, 2008
- Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffoldBioorganic & Medicinal Chemistry Letters, 2008
- Characterization of a CNS penetrant, selective M1muscarinic receptor agonist, 77‐LH‐28‐1British Journal of Pharmacology, 2008
- The role of acetylcholine in learning and memoryCurrent Opinion in Neurobiology, 2006