Fibrinolysis and Afibrinogenemia

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Abstract
In recent years it has become apparent that an ever increasing number of medical, surgical and obstetrical states may be further complicated by the development of hypofibrinogenemia and a serious hemorrhage diathesis which may profoundly affect the outcome for the patient. Since this is an area of active investigation, information concerning the pathogenesis, diagnosis and management of these disorders is rapidly accumulating, and new concepts continue to emerge. The circumstances under which these events occur are most commonly those capable of precipitating disseminated intravascular clotting and/or abnormal states of fibinolysis. These two phenomena, either singly or in combination, are responsible for most of the disorders. Effective agents for the treatment of such problems are already available and newer ones are under development, but the scientific basis of this subject must be further elaborated before the therapeutic approach can be entirely rational.