Resequencing and mutational analysis using oligonucleotide microarrays
- 1 January 1999
- journal article
- review article
- Published by Springer Nature in Nature Genetics
- Vol. 21 (S1) , 42-47
- https://doi.org/10.1038/4469
Abstract
Oligonucleotide microarray (DNA chip)-based hybridization analysis is a promising new technology which potentially allows rapid and cost-effective screens for all possible mutations and sequence variations in genomic DNA. Here, I review current strategies and uses for DNA chip-based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip-based assays.Keywords
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