A Leukemogenic Filtrable Agent from Chemically-Induced Lymphoid Leukemia in C57BL Mice

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Abstract
Thymic lymphomas were induced in 60% of C57BL mice fed with 7,12-dimethylbenz(a)anthracene [DMBA] dissolved in polyethylene glycol 400, the mean latent period from the start of the DMBA feedings being 176 days. Three series of cell-free filtrates prepared from the DMBA-induced lymphomas Were leukemogenic, producing 15-27% lymphomas in the tested mice. Serial cell-free passages of the original filtrate-induced lymphomas revealed a similar leukemogenic activity of 10-30%.