VESICO‐URETERIC REFLUX IN DOWN'S SYNDROME: POOR PROGNOSIS

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Abstract
Four patients with Down's syndrome and vesico‐ureteric reflux (VUR) are reported. VUR was diagnosed in six renal units and three primary nephrectomies were necessary. Three ureters were reimplanted unsuccessfully in two patients. The 50% nephrectomy rate for reflux nephropathy and the 100% failure rate for ureteric reimplantation in Down's syndrome patients are compared with a nephrectomy rate and ureteric reimplantation failure rate of around 1% for primary VUR in other children.