Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells.
- 1 June 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (12) , 3670-3674
- https://doi.org/10.1073/pnas.81.12.3670
Abstract
An N-ras-related transforming gene was detected in the human lung carcinoma cell line SW-1271 and molecularly cloned. The lesion responsible for its acquisition of transforming activity was localized to a single nucleotide transition from A to G in codon 61 of the predicted protein. This lesion in the 2 exon results in the substitution of arginine for glutamine at this position. The activation of ras oncogenes in human tumors apparently is most commonly due to point mutations at 1 of 2 major hot spots in the ras coding sequence.Keywords
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