GAMMA1-ANTIBODIES IN GUINEA-PIGS INFECTED WITH CATTLE LUNGWORM

  • 1 January 1966
    • journal article
    • research article
    • Vol. 11  (3) , 199-+
Abstract
The parameters of a system for testing both actively acquired and passive immunity to the cattle lungworm in the guinea pig are described. It was found that the passive transfer of guinea pig immunoglobulins conferred a strong immunity. The globulins responsible for immunity were present in a serum fraction containing electrophoretically fast moving globulins and anaphylactic activity. Guinea pigs were not protected by artificial immunization with adult worm homogenate even though precipitating and anaphylactic antibodies were produced. Artificial immunization may have failed because [gamma]1- and [gamma]2-antibodies were produced against irrelevant antigens or because blocking [gamma] 2-antibody was produced in excess.