Study on the Specificity of -Tocopheryl (Vitamin E) Acid Succinate Effects on Melanoma, Glioma and Neuroblastoma Cells in Culture

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Abstract
Both d- and dl-.alpha.-tocopheryl succinate inhibited growth and caused morphological changes in mouse melanoma (B-16), mouse neuroblastoma (NBP2) and rat glioma (C-6) cells in culture. To study whether the effects of .alpha.-tocopheryl (vitamin E) succinate on tumor cells are mediated by antioxidant mechanisms, the effects of lipid-soluble antioxidants, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were compared with those of vitamin E succinate. These antioxidants produced alterations on the growth and morphology of neuroblastoma, melanoma and glioma cells which are similar to those produced by vitamin E succinate; the extent of the effect depended on the type of antioxidant and the form of tumor cells. The effects of vitamin E succinate on tumor cells may be mediated, in part, by antioxidant mechanisms.