The Effect of Propylthiouracil on the Periodontium of the Hamster

Publisher Website
Google Scholar
Abstract
Propylthiouracil was admd. in the drinking water in dosages from 0.05 to 0.10% to young adult hamsters for 186 and 449 days. In addition, 4 generations of animals were raised under the continuous influence of this drug. No differences between the control and exptl. animals were demonstrated by measurements of water intake, activity indices, oxygen consumption, and serum cholesterol. Growth was inhibited in the exptl. animals as evidenced by a lag in wt. gain, decreased femur length, and histological findings in the femurs. The treated thyroid glands exhibited remarkable and consistent hyperplasia, grossly and microscopically. No increase in periodontal pathology due to this drug was noted.