A STUDY OF LIPOTROPIC FACTORS DERIVED FROM THE PANCREAS

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Abstract
Extracts of pancreas when admd. orally to dogs raise the level of blood lipids which has been caused to fall by ligation of the pancreatic ducts. Dragstedt''s extract (lipocaic) also prevents the fatty liver which occurs when rats are placed upon a high-fat, low-protein diet; Chaikoff''s extract does not. Inositol, choline, or both together have no influence upon the dietary fatty liver of the rat when given in amts. equivalent to those found in lipocaic. Inositol orally or parenterally and crystalline trypsin, chymotrypsin and carboxypeptidase by moulh are not lipotropic in the pancreatic duct-ligated dog.