FAILURE TO ISOLATE CORTISOL FROM A PHEOCHROMOCYTOMA*

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Abstract
A pheochromocytoma with an attached fragment of nontumorous adrenal tissue, removed from a 37-year-old woman, was studied by histochemical and incubation-chromatographic techniques. The normal adrenal tissue slices released, on the average, 48.4 [mu]g of hydrocrotisone per gm. (148.2 [mu]g. after stimulation with ACTH, adrenocorticotropic hormone); 17.0 [mu]g. of cortisone (20.4 [mu]g. after ACTH); and 5.4 [mu]g. of aldosterone (2.8 [mu]g. after ACTH). No steroid was released, however, by the slices of pheochromocytoma, even after stimulation with ACTH. A weak-to-moderate chromaffin reaction was observed throughout the tumor tissue.