A radioprotective effect of vitamin C observed in Chinese hamster ovary cells
- 1 August 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 50 (596) , 587-591
- https://doi.org/10.1259/0007-1285-50-596-587
Abstract
Vitamin C at high concentrations inhibited the growth of CHO [Chinese hamster ovary] clone A cells in culture. It had a radioprotective effect, giving a maximum increase in cell survival of a factor of 7 under the experimental conditions used. The protective effect was mainly but not exclusively attributable to an increase in the Do [exponential decline], the maximum increase observed being the order of 1.4.This publication has 13 references indexed in Scilit:
- Results and analysis of tumour levels of ascorbic acidIrish Journal of Medical Science, 1977
- Radiosensitization of C3H mouse mammary tumours using fractionated doses of X rays with the drug Ro-07–0582The British Journal of Radiology, 1976
- The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancerChemico-Biological Interactions, 1974
- The orthomolecular treatment of cancer I. The role of ascorbic acid in host resistanceChemico-Biological Interactions, 1974
- The effect of bleomycin and radiation in combination on bacteria and mammalian cells in cultureThe British Journal of Radiology, 1974
- The R.B.E. of60Co Gamma Rays with Respect to 300 kVp X-rays for the Survival of HeLa S-3 and CHO Cells, Irradiated in Different States of ProliferationInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1974
- The use of a television image analysis system to determine the number and size distribution of mammalian cell clonesThe British Journal of Radiology, 1973
- The Effect of Hypertonic Shock on the Radiation Response of HeLa-3 CellsInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1972
- Antitumor potency of ascorbic, dehydroascorbic or 2, 3-dike-togulonic acid and their action on deoxyribonucleic acidZeitschrift für Krebsforschung und Klinische Onkologie, 1971