THE ABILITY OF CERTAIN ADRENAL STEROIDS TO RESTORE REPRODUCTION IN ADRENALECTOMIZED FEMALE RATS

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Abstract
MANY of the early experiments concerned with the relation of the adrenal gland to reproduction were complicated because the survival time of the adrenalectomized animals was too short to allow a systematic study of reproduction. They were further complicated by the presence of accessory cortical tissue in the animals that survived. Following adrenalectomy, Martin (1932) found prolonged estrous cycles or cessation of estrus in 87.2% of 121 rats. The survival time following adrenalectomy ranged from 7 to 27 days. He reported normal cycles in 12.8% of the rats following adrenalectomy, but none of these rats survived longer than nine days. The short survival time of these latter animals was inadequate to establish normality of the cycles. Deansley (1928) reported normal reproduction in adrenalectomized rats. Courrier, Baclesse and Marois (1953) reported a species difference with respect to the effect of cortisone on reproduction.

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