Effect of chloroquine and some other antimalarials on the immune mechanism in experimental animals
- 1 April 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (4) , 268-269
- https://doi.org/10.1111/j.2042-7158.1984.tb04366.x
Abstract
The effects of chloroquine and some other antimalarials on the immune responses in experimental animals have been examined. Chloroquine and quinine caused significant decrease of serum anti−SRBC haemagglutination titre. Chloroquine lowered the serum IgM level and also reduced plaque−forming cells in the spleen of mice. The delayed−type hypersensitivity responses to SRBC and the passive cutaneous anaphylaxis were also diminished in rats treated with chloroquine. Thus, the immunosuppressant activity of chloroquine may explain its efficacy in various types of immune disorders.Keywords
This publication has 7 references indexed in Scilit:
- Prostaglandins and the immune responseLife Sciences, 1977
- The Effect of Salicylate and Chloroquine on Prostaglandin-Induced Articular Damage in the Rabbit KneePublished by Wolters Kluwer Health ,1975
- Human lymphocyte metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutininJournal of Clinical Investigation, 1971
- The Chloroquine MysteryArchives of Dermatology, 1966
- The chloroquine mysteryArchives of Dermatology, 1966
- Antibodies to denatured deoxyribonucleic acid in lupus erythematosus serum. V. Mechanism of DNA-anti-DNA inhibition by chloroquineArchives of Biochemistry and Biophysics, 1963
- THE DETERMINATION OF ASCORBIC ACID IN WHOLE BLOOD AND URINE THROUGH THE 2,4-DINITROPHENYLHYDRAZINE DERIVATIVE OF DEHYDROASCORBIC ACIDJournal of Biological Chemistry, 1943