Iodine Absorption from the Gastrointestinal Tract During Hypaque-Enema Examination

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Abstract
Iodinated contrast agents administered i.v. or intra-arterially may cause serious reactions in hypersensitive patients. Oral administration of Hypaque (diatrizoate sodium) results in minimal absorption of I, but the amount of I absorbed with Hypaque-enema studies is unreported. Hypaque-enema examinations were performed in 20 normal, nonsensitive patients and increased serum I levels 10-200 times base-line values, peaking after .apprx. 1 h in patients who had measurements obtained for 4 h. Before Hypaque-enema studies, patients must be carefully questioned about their tolerance of iodinated contrast agents, and preparations should be made for possible serious hypersensitivity reactions.