Oral contraceptive and platelet lipid biosynthesis in female rats: Dose‐response relationship
- 1 February 1982
- Vol. 17 (2) , 111-114
- https://doi.org/10.1007/bf02535185
Abstract
Female rats were treated with different doses of an oral contraceptive (ethinyl estradiol + lynestrenol) and lipid biosynthesis was studied in blood platelets by acetate incorporation into different fractions separated by thin layer chromatography. A marked increase in lipid biosynthesis was observed, especially in the sterol fractions (cholesterol and lanosterol‐dihydrolanosterol). It was dose‐dependent, observed after a lag‐phase, maximal in 3 days and normalized in 8 days. Thus, the oral contraceptive studied here appears to modify platelet lipid biosynthesis for the entire life of the platelets.This publication has 11 references indexed in Scilit:
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