Antidiuretic Action of Chlorpropamide in Idiopathic Diabetes Insipidus

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Abstract
Chlorpropamide was given to 3 patients with idiopathic diabetes insipidus and 2 with nephrogenic diabetes insipidus. Its influence on urine flow, free water and osmolal clearances as well as on blood sugar was studied. A sharp antldiuretic response was observed in the first 3 patients. Although the antidluretic mechanism of chlorpropamide is not yet known, there is a strong suggestion that it acts in a way similar to that of the antldiuretic hormone, at least in some respects. The possibilltyof the use of chlorpropamide in the treatment of idiopathic diabetes insipidus is suggested.