EARLY HEMATOPOIETIC RESPONSES TO SALMONELLA-TYPHIMURIUM INFECTION IN RESISTANT AND SUSCEPTIBLE MICE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 45  (2) , 395-399
Abstract
The response of colony forming cells in the bone marrow and spleen of resistant (CBA) and susceptible (C57BL) mice to S. typhimurium infection was studied for 4 days after infection. The number and size of the colonies were assessed. The resistant strain exhibited an immediate response to challenge, sharply increasing the number of colonies to 2.5 times normal over 2-3 days after infection. The susceptible strain gave a slowly increased response to the same challenge which never exceeded 1.2 times normal and fell to 0.8 times the normal. When mouse strain were immunized there was a clear distinction between the spenic and bone marrow cellularity. Immunization appeared to enhance the splenic cellularity in resistant mice but failed to in susceptible mice. In the bone marrow of susceptible mice there was some evidence of an elevated response.