Immunohistochemical characterization of an amphicrine mucinous islet‐cell carcinoma of the pancreas

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Abstract
Immunohistochemical characteristics of a mucinous islet‐cell carcinoma of the pancreas are described. The tumour presented with jaundice in a 59‐year‐old male. It consisted of polygonal atypical cells forming a reticular pattern, and invaded the common bile duct. In DNA flow cytometry, the tumour cells showed a clear‐cut aneuploid peak. Intercellular mucin was abundant. A panel of antisera and monoclonal markers was applied in the immunohistochemical analysis. In addition to general epithelial and endocrine markers, the tumour cells showed a focal positive immunoreaction with anti‐glucagon, anti‐insulin, anti‐vasoactive intestinal polypeptide, anti‐pancreatic secretory trypsin inhibitor and antiphospholipase A2 antigen. At the ultrastructural level, mucous and neuroendocrine granules were demonstrated in the same tumour cells.