A STUDY ON THE ESTRADIOL-INDUCED AUGMENTATION OF A SPECIFIC CELL PRODUCT IN THE VAGINAL EPITHELIUM OF THE NEONATAL MOUSE

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Abstract
The epithelial content of an estradiol-sensitive immunological marker (CVA, cervicovaginal antigen) was quantified by mixed hemagglutination on tissue sections from the vagina of neonatal mice exposed to different schedules of estradiol treatment. Daily administration of estradiol-17.beta. (E2, 5 .mu.g/day) was especially efficient in elevating the CVA content when the hormone was administered during the first 4 days after birth. Following a single injection of E2 (5 .mu.g in aqueous suspension) on one of the first 5 days of life, the vaginal epithelium reacted with a more vigorous CVA accumulation when challenged with E2 at a later time. The effect was most pronounced for days 2 and 3. The possibility that this early effect of E2 may involve other mechanisms than those operative in the E2 action at later stages, is discussed.

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