Stimulation of Growth Hormone Secretion by Vasopressin in the Rhesus Monkey1

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Abstract
The influence of Pitressin and synthetic lysine-vasopressin administration on pituitary growth hormone secretion was investigated in unanesthetized rhesus monkeys restrained in primate chairs. Plasma growth hormone concentration was measured by radioimmunoassay in blood samples obtained from indwelling catheters at 5- to 15-min intervals. It was found that Pitressin and lysine-vasopressin in single intravenous doses of 0.1-0.3 U/kg produced prompt increases in plasma growth hormone concentration which returned to control levels 1-2 hr after injection. It is concluded that vasopressin can stimulate growth hormone secretion but that this action may not be a specific one.