Substances Present at the Hypothalamic Level and Growth Hormone Releasing Activity

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Abstract
In order to clarify the nature of the substance responsible for the growth hormone releasing activity of hypothalamic extracts, the following physiological constituents of hypothalamic tissue were assayed as growth hormone releasers in normal rats: vasopressin, oxytocin, serotonin, histamine, epinephrine and acetylcholine. Unlike hypothalamic extract, no one of the above-mentioned compounds proved to be able to diminish growth hormone pituitary content after intracarotid injection. These results seem to support the existence of a neurohumoral factor (s) specifically concerned with growth hormone release.