OVARIAN WEIGHT INCREASE AS AN OBJECTIVE MEASURE FOR ASSAY OF PROLAN

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Abstract
Three graded doses of prolan, each differing from the next lowest by 100%, were administered to immature [male] rats of the Evans strain and to mature virgin mice of the Marsh-Buffalo strain. In the expts. with 22-day-oId rats, one series received 10 divided doses in 5 days, and one series received 4 doses in 4 days augmented with pituitary gonadotrophic hormone. In a 3d expt., dosage was begun at the age of 30 days. In the expts. with 100-day-old mice a comparison was made between the influence of 10 divided doses and 4 divided doses. Statistical analyses of the results obtained indicated that ovarian hypertrophy is as satisfactory an objective measure as uterine hypertrophy if the conditions are properly chosen.