Specification of the Adsorption Model in Hydroxyapatite Chromatography. III. Competition Model in Gradient Chromatography and Another Relevant Model

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Abstract
If a component of the multicomponents adsorbed system argued in the preceding paper is assigned to the ions from the buffer solvent and the other components to the respective molecular species in the sample mixture, the competition model in gradient chromatography can be derived. In relationship with the competition model, another chromatographic model is also proposed. Whereas the competition model is applicable to the usual hydroxyapatite chromatography carried out in an aqueous medium, the new model is probably valid in a special case of hydroxyapatite chromatography carried out in the presence of an organic solvent and, at least in some cases, of reversed phase chromatography